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Myasthenia Gravis  //

Myasthenia Gravis

 

Myasthenia Gravis (MG) is an autoimmune disease of the muscle causing muscle weakness and fatigue. It afflicts about 60,000 individuals in the United States and around a million worldwide. In 80% of MG patients, antibodies (Y) to acetylcholine receptor (AChR) and complement (C) destroy the neuromuscular junction (NMJ) architecture and leads to deficiency of AChR. MG is usually diagnosed by the presence of antibodies to acetylcholine receptor (AChR), muscle specific kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4).